Our Technology


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Slope Spectroscopy® is fundamentally a UV-Vis technique based upon the Beer-Lambert law, that delivers rapid, reliable results from easy-to-use solutions for concentration determination and other UV-Vis applications. Scientists no longer need to adapt their samples to their measurement device with the costly and error-prone dilution and background corrections steps required by traditional absolute-absorbance methods. Leveraging the power and flexibility of our Variable Pathlength Technology, Slope Spectroscopy methods adapt to the sample being measured by characterizing the absorbance at multiple pathlengths ensuring compliance with the Beer-Lambert law and providing users the opportunity for greater insights about their samples and their processes. One of the most common applications of the technology is the measurement of sample concentration (e.g., proteins, biologics, biosimilars, etc.) based on the slope of the Absorbance-Pathlength (Section) Plot, since the slope value is directly proportional to the concentration of the sample based upon the sample Extinction Coefficient.

Since its introduction in 2007, with the release of the SoloVPE Solution, use of variable pathlength technology and the Slope Spectroscopy technique has continued to accelerate, with increasing numbers of applications, deployed methods and installations around the globe. The introduction of the FlowVPE Solution in 2014 enabled slope-based methods for online and in-process applications giving engineers and scientists a powerful new tool for process monitoring and real-time sample characterization. Variable Pathlength Technology has emerged as a standard platform for UV-Vis methods across organizations, supply chains, products, and process streams due to the simplicity, adaptability, value, and reliability of the tools and the technique.

Are you unfamiliar with the technology? You may be like so many others before who have asked, “Why didn’t anyone ever think of this before?”. Contact us today for more information and remember… Don’t change your sample. Change your measurement system.